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疼痛與炎癥研究

足底痛覺測量儀

時間:2016-09-20來源:本站作者:玉研儀器

詳細介紹

足底痛覺測量儀(大小鼠足底熱測痛儀,熱刺激痛覺測試儀,Hargreaves Method,Plantar Test Apparatus for Mice and Rats測試大鼠和小鼠的疼痛反應時間,進行快速精確地篩選麻醉型鎮痛藥物,更多詳情敬請來電咨詢)


型號:390型、390G型

 

足底痛覺實驗用于測試鎮痛藥物影響無束縛大鼠對外部熱刺激的反應時間,使用時先通過從爪下面的測試頭發出導向光將光源移到動物爪底,通過反光鏡確定位置,避免頻繁彎腰和低頭,方便操作,啟動加熱光束照射到動物爪底進行實驗。

 

The Plantar Analgesia Meter for thermal paw can be used on 12 mice, 6 rats and other animals (cats, rabbits) unrestrained when testing for narcotic drugs. Experiments are easy to perform, simply slide the test head under test subject, align the heat source via our exclusive guide light (idle state) by the attached, adjustable, angled mirror on test head to test subject and perform tests.

 

足底熱測痛儀主要特點: 

 

? 精確數字控制, 時間精確度為0.01

? 自動切斷保護功能

? 光束強度可調節,步進量1

? 手工結束測試,減少誤觸發

? 強制取消定時器功能

? 數字顯示功能

? 動物不需固定限制

? 加熱玻璃可選配

? 測試頭具有反光鏡輔助觀察

? 標準計算機打印口輸出

? 型號:390 爪刺激痛覺測試儀

? 型號:390G 爪刺激痛覺測試儀內置熱玻璃

 

足底熱測痛儀技術參數:

 

? 可見光法測試、精確數字程控

? 適用于小鼠、大鼠、貓、兔等實驗動物,動物無需固定全自然狀態下測試

? 2通道大鼠或4通道小鼠(最多可達6通道大鼠或12通道小鼠)

? 刺激光可調,范圍從室溫~250℃

? 計時器精度:0.1

? 按鈕及腳踏開關控制啟動、停止和重設實驗

? 探視鏡及玻璃板角度可調

? 引導光線協助定位

? 自動斷電關閉設計,人道避免動物組織損傷

? USB RS232 標準

? 電壓范圍120v~240V

? 通過CE認證

? 獨家選配加熱玻璃板,溫度調節范圍30~40℃

? 獨家選配數據采集軟件



部分參考文獻:


Peripherally acting mu-opioid receptor agonist attenuates neuropathic
pain in rats after L5 spinal nerve injury
Y Guan, LM Johanek, TV Hartke, B Shim, YX Tao… - Pain, 2008 - Elsevier
... Abrupt paw-withdrawal, licking, and shaking were regarded as positive responses. To test for
signs of heat hyperalgesia, paw-withdrawal latencies (PWLs) to radiant heat stimuli [19] were
measured with a plantar stimulator analgesia meter (IITC model 390, Woodland Hills, CA). ...

 

Sex-specificity and estrogen-dependence of kappa opioid
receptor-mediated antinociception and antihyperalgesia
KP Lawson, S Nag, AD Thompson, SS Mokha - Pain, 2010 - Elsevier
... 2.8. Paw withdrawal assays. Thermal hyperalgesia was measured using a plantar
analgesia meter (IITC model 390, Woodland Hills, CA), as described originally by
Hargreaves [25]. Animals were placed in a clear plastic cage ...

Antinociceptive effects of MSVIII-19, a functional antagonist of the
GluK1 kainate receptor
CS Qiu, LLV Wyhe, M Sasaki, R Sakai, GT Swanson… - Pain, 2011 - Elsevier
... Mice were placed in individual 10 × 10 × 15-cm plastic boxes on a glass floor of the
apparatus (model 390, IITC Life Science) and allowed to acclimate for at least 30 minutes
before drug or vehicle injection. Each paw was tested at least 3 times. ...

Low-frequency electroacupuncture suppresses carrageenan-induced paw
inflammation in mice via sympathetic post-ganglionic neurons, while
high-frequency EA …
HW Kim, DK Uh, SY Yoon, DH Roh, YB Kwon… - Brain research …, 2008 - Elsevier
... responses to noxious thermal stimuli, paw withdrawal latency was evaluated based on a
previously described procedure [8]. Briefly, a radiant heat source was positioned beneath the
hind paw in thermal tester (IITC 390 plantar tester, IITC Life Science, Woodland Hills, CA USA). ...

Macrophage inflammatory protein-1α mediates the development of
neuropathic pain following peripheral nerve injury through interleukin-1
β up-regulation

N Kiguchi, T Maeda, Y Kobayashi, Y Fukazawa… - Pain, 2010 - Elsevier
... 2.6. Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency using
the IITC 390 Plantar Test Analgesia Meter (Neuroscience, Tokyo, Japan). Mice were
placed on top of a glass sheet, and covered with a clear cage. ...

CC-chemokine MIP-1α in the spinal cord contributes to nerve
injury-induced neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, F Saika… - Neuroscience …, 2010 - Elsevier
... Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test
Analgesia Meter (Neuroscience). Mice were placed on a glass sheet and covered with a
clear cage. Mice were allowed to adapt for 2–3 h before the test. ...

Transient heat hyperalgesia during resolution of ropivacaine sciatic
nerve block in the rat
LM Kolarczyk, BA Williams - Regional anesthesia and pain …, 2011 - ncbi.nlm.nih.gov
... min to a raised, fenestrated stainless-steel table (which provided access to the plantar aspect
of each hindpaw for application of von Frey monofilaments from below), followed by a minimum
of 5 min acclimation on a glass thermal (34°C) table apparatus (IITC? 390 Plantar Test ...

Suppressive effect of imipramine on vincristine-induced mechanical
allodynia in mice
F Saika, N Kiguchi, Y Kobayashi, Y Fukazawa… - Biological and …, 2009 - jlc.jst.go.jp
... before morphine administration)(value of % response at 30 min after morphine administration)]/(
value of % response before morphine administration) Thermal Paw Withdrawal Test Thermal
hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test ...

CC‐chemokine ligand 4/macrophage inflammatory protein‐1β
participates in the induction of neuropathic pain after peripheral nerve
injury
F Saika, N Kiguchi, Y Kobayashi… - … Journal of Pain, 2012 - Wiley Online Library
... 2.3 Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency
using the IITC 390 Plantar Test Analgesia Meter (Neuroscience). The mice were
placed on the top of a glass sheet and covered with a clear cage. ...

Epigenetic augmentation of the macrophage inflammatory protein 2/CXC
chemokine receptor type 2 axis through histone H3 acetylation in injured
peripheral nerves …

N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa… - … of Pharmacology and …, 2012 - ASPET
... Mice were allowed to adapt for 2 to 3 h before the test. The radiant heat source,
IITC 390 Plantar Test Analgesia Meter (Neuroscience), was positioned under the
glass sheet and applied to the plantar surface of the hind paw. ...

Activation of extracellular signal-regulated kinase in sciatic nerve
contributes to neuropathic pain after partial sciatic nerve ligation in
mice
N Kiguchi, T Maeda, Y Kobayashi… - Anesthesia & …, 2009 - journals.lww.com
Advertisement. Close Window. Close Window. Enter your Email address: Wolters Kluwer Health
may email you for journal alerts and information, but is committed to maintaining your privacy
and will not share your personal information without your express consent. ...

Learning and memory with neuropathic pain: impact of old age and
progranulin deficiency
B Albuquerque, A H?ussler, E Vannoni… - Frontiers in …, 2013 - ncbi.nlm.nih.gov
... Heat hyperalgesia was assessed by recording the paw withdrawal latency in the Hargreaves
Test (IITC 390 Plantar Test), in which a radiant heat source is placed underneath the hind paw
with a mirror system and applies radiant heat upon pressure of a button. ...

Activation of nicotinic acetylcholine receptors on bone marrow-derived
cells relieves neuropathic pain accompanied by peripheral
neuroinflammation
N Kiguchi, Y Kobayashi, T Maeda, S Tominaga… - Neurochemistry …, 2012 - Elsevier
... The radiant heat source, IITC 390 Plantar Test Analgesia Meter (Neuroscience), was
positioned under the glass sheet and applied to the plantar surface of the hind paw. Thermal
hyperalgesia was designed as the mean latency of three stimulations. ...

Epigenetic augmentation of the MIP-2/CXCR2 axis through histone H3
acetylation in injured peripheral nerves elicits neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa… - … of Pharmacology and …, 2011 - ASPET
... Mice were allowed to adapt for 2–3 h before the test. The radiant heat source, IITC 390 Plantar
Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the
plantar surface of the hind paw. Withdrawal latencies were measured three times ...

A practitioner report on the evaluation of the performance of the C, C++
and Java compilers on the OS/390 platform
DA Cargill, M Radaideh - Performance Analysis of Systems and …, 2000 - ieeexplore.ieee.org
... To do this analysis, we iise tlie pcrformnncc tools availablc on thc OS/390 platihnn, specifically
thc PerTonnnncc Analyzcr from IBM [2] atid Strobctg ... I-Iowcver, wc realize that
cotii~~iitc-iiiterisivc
bcrichti~irks do iiot STI'CSS he opcratiiig syslcin or llic 110 siibsystciii and iiiay not bc ...

Pentoxifylline attenuates the development of hyperalgesia in a rat model
of neuropathic pain
J Liu, X Feng, M Yu, W Xie, X Zhao, W Li, R Guan… - Neuroscience …, 2007 - Elsevier
... Five tests were conducted at intervals of 5 min and the force (g) applied was recorded.
Thermal sensitivity was determined by using paw withdrawal latencies to radiant
heat (Model 390, IITC Life Science, INC.). After animals ...

Effect of betamethasone on neuropathic pain and cerebral expression of
NF-κB and cytokines
W Xie, X Liu, H Xuan, S Luo, X Zhao, Z Zhou, J Xu - Neuroscience letters, 2006 - Elsevier
... The threshold of paw withdrawal to noxious heat stimuli was measured using a paw stimulator
analgesia meter (Model 390, IITC Life Science, Inc.). Rats were placed on a 6-mm thick glass
floor under an inverted clear Plexiglas cage and were allowed to acclimatize for 10 min. ...

Topical application of l-menthol induces heat analgesia, mechanical
allodynia, and a biphasic effect on cold sensitivity in rats
AH Klein, CM Sawyer, MI Carstens… - Behavioural brain …, 2010 - Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar
surface of the hind paw through the glass plate from below, and the latency from onset
of the light to brisk withdrawal of the stimulated paw was measured. ...

Behavioral evidence of thermal hyperalgesia and mechanical allodynia
induced by intradermal cinnamaldehyde in rats
MG Tsagareli, N Tsiklauri, KL Zanotto, MI Carstens… - Neuroscience …, 2010 - Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar
surface through the glass floor from below, and the latency from onset of the light
to brisk withdrawal of the stimulated paw was measured. ...

Vascular endothelial growth factor signaling in injured nerves underlies
peripheral sensitization in neuropathic pain
Tel021-35183767 Http://www.diyztf.live
N Kiguchi, Y Kobayashi, Y Kadowaki… - Journal of …, 2014 - Wiley Online Library
... The mice were allowed to adapt for 2–3 h before the test. The radiant heat source,
IITC 390 Planter Test Analgesia Meter (Neuroscience), was positioned under the
glass sheet and applied to the plantar surface of the hind paw. ...

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